USP25/28 inhibitor AZ1

中文名	USP25 and 28 inhibitor AZ-1
英文名	USP25/28 inhibitor AZ1； AZ1
别名	化合物AZ1 2-[[[5-溴-2-[[4-氟-3-(三氟甲基)苯基]甲氧基]苯基]甲基]氨基]-乙醇
英文别名	AZ1 AZ-1 AZ 1 USP25 and 28 inhibitor AZ-1 2-((5-bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethanol Ethanol, 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-
CAS	2165322-94-9
化学式	C17H16BrF4NO2
分子量	422.21
密度	1.488±0.06 g/cm3(Predicted)
沸点	478.5±40.0 °C(Predicted)
溶解度	DMSO : 250 mg/mL (592.12 mM);H2O : < 0.1 mg/mL (不溶)
酸度系数	14.74±0.10(Predicted)
存储条件	-20°C
体内研究	USP25/28 inhibitor AZ1 (AZ1; 40 mg/kg; gavage; daily; for 7 days) protects from dextran sulfate sodium (DSS)-induced weight loss and diarrhea and impaired colon shortening. USP25/28 inhibitor AZ1 (20 mg/kg/day; gavage; 6 times a week in the 1, 3, 6 weeks) treatment significantly reduces tumor numbers in colons. Expression of Wnt-related genes and levels of pSTAT3 are decreased and levels of SOCS3 are increased in tumors. AZ1 gavage does not alleviate DSS-induced colitis in Usp25 -/- mice or the spontaneous colitis of Il10 -/- mice. USP25/28 inhibitor AZ1 (20 mg/kg/day; gavage; every 3 days from 13-20 weeks) significantly inhibits tumorigenesis in the colon and prolonged the survival of AOM/Vil-Cre;Trp53 fl/fl (VP) mice. AZ1 treatment has minimal effect on tumorigenesis in the USP25-deficient background. Animal Model: 12-week old male Usp25 +/+ and Usp25 -/- mice Dosage: 40 mg/kg Administration: Gavage; daily; for 7 days Result: Protected from dextran sulfate sodium (DSS)-induced weight loss and diarrhea and impaired colon shortening and potentiated the expression of proinflammatory cytokines and antibacterial peptides in colons of Usp25 -/- mice compared to control counterparts.

USP25/28 inhibitor AZ1 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.368 ml	11.842 ml	23.685 ml
5 mM	0.474 ml	2.368 ml	4.737 ml
10 mM	0.237 ml	1.184 ml	2.368 ml
5 mM	0.047 ml	0.237 ml	0.474 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

现货供应

产品名: USP25/28 inhibitor AZ1 去供应商网站查看询盘
CAS: 2165322-94-9
产地: 北京
包装: 盒
规格: IU0420-1mg,1mg
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上海吉至生化科技有限公司

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产品名: USP25/28 inhibitor AZ1 去供应商网站查看询盘
CAS: 2165322-94-9
产地: 中国上海
包装: 25mg
规格: 98%
价格: 7998.00
库存: 现货
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产品描述: 中文名：USP25/28 inhibitor AZ1 英文名:USP25/28 inhibitor AZ1 CAS:2165322-94-9 规格:98% 产地更多

上海麦克林生化科技股份有限公司

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产品名: USP25 and 28 inhibitor AZ-1 去供应商网站查看询盘
CAS: 2165322-94-9
产地: 上海
规格: U910574
价格: 250mg-3499,100mg-2054,25mg-806,10mg-500,1ml-720
库存: 7天内发货
电话: 13816333479/13918391375
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上海源叶生物科技有限公司

产品名: USP25 and 28 inhibitor AZ-1 去供应商网站查看询盘
CAS: 2165322-94-9
产地: 上海
规格: 98%
价格: 5mg 2000,10mg 3500,25mg 7000,50mg 12000,100mg 20000
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